John Stamos is showing unwavering support for his _Full House_ co-star Lori Loughlin as she navigates the challenging separation from her husband of 27 years, Mossimo Giannulli. In a heartfelt and candid conversation on the _Good Guys_ podcast on October 20, 2025, Stamos opened up about his deep concern for Loughlin, describing her as “devastated” by the situation.
Stamos’ Straightforward Assessment of Giannulli
Stamos didn’t mince words when discussing Giannulli, labeling him a “terrible narcissist”. His strong stance is clear: “I will never talk to him again”. Stamos believes Giannulli’s actions have profoundly hurt Loughlin, stating they “busted her up to the core”. He reflects that Loughlin “put up with a lot over the years with this guy”, underscoring his perception of her enduring challenges within the marriage
Highlighting his longstanding bond with Loughlin, Stamos praises her as “a good person, a good mother, a good wife”. He recalls standing by her through significant turmoil, notably the college admissions scandal. Both Loughlin and Giannulli pleaded guilty to wire and mail fraud connected to their daughters’ admission to the University of Southern California (USC), resulting in prison sentences – two months for Loughlin and five months for Giannulli
Stamos shared an insightful anecdote about Loughlin’s experience in prison, showcasing her characteristic grace: “In typical Lori fashion… She goes, ‘You know, I met a lot of nice ladies in there. We have a book club.'” This story encapsulates her strength and adaptability. Stamos reiterated his commitment to supporting her, stating he’s “really tried to be there for her during this time”
Loughlin and Giannulli announced their split on October , 2025. Their representative confirmed they are “living apart and taking a break from their marriage”, with no legal proceedings initiated at the time of the announcement. The couple, married for nearly 28 years, shares two daughters, Olivia Jade and Isabella Rose 
Reports suggest the separation might stem from trust issues, with allegations of incriminating messages found on Giannulli’s phone being a breaking point for Loughlin. Despite their public reconciliation post-scandal, insiders indicate the marriage had been strained, with Loughlin reportedly feeling “betrayed”. As Loughlin focuses on healing and moving forward, she’s leaning on her family, friends like James Tupper, and new professional endeavors